Takehiko Koji Selected Research

Fibroblast Growth Factor 7

10/2015	In vivo over-expression of KGF mimic human middle ear cholesteatoma.
6/2015	Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice.
11/2014	KGFR as a possible therapeutic target in middle ear cholesteatoma.
1/2012	Expression of keratinocyte growth factor (KGF) and its receptor in a middle-ear cavity problem.
7/2010	Expression of keratinocyte growth factor and its receptor in noncholesteatomatous and cholesteatomatous chronic otitis media.
10/2008	Topical application of 5-fluorouracil on attic cholesteatoma results in downregulation of keratinocyte growth factor and reduction of proliferative activity.
12/2004	Expression of keratinocyte growth factor and its receptor in human breast cancer: its inhibitory role in the induction of apoptosis possibly through the overexpression of Bcl-2.
11/2004	Estrogen receptor-associated expression of keratinocyte growth factor and its possible role in the inhibition of apoptosis in human breast cancer.
9/2004	Expression of keratinocyte growth factor/fibroblast growth factor-7 and its receptor in human lung cancer: correlation with tumour proliferative activity and patient prognosis.
1/2003	Possible involvement of keratinocyte growth factor and its receptor in enhanced epithelial-cell proliferation and acquired recurrence of middle-ear cholesteatoma.

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Takehiko Koji Research Topics

Disease

18	Peritoneal Fibrosis 03/2022 - 01/2003
12	Neoplasms (Cancer) 12/2021 - 08/2002
9	Inflammation (Inflammations) 03/2022 - 12/2003
7	Ischemia 05/2020 - 03/2003
6	Infections 01/2019 - 04/2003
6	Fibrosis (Cirrhosis) 01/2017 - 01/2008
6	Glomerulonephritis 12/2012 - 12/2000
5	Cholesteatoma 11/2014 - 01/2003
4	Middle Ear Cholesteatoma 10/2015 - 01/2003
3	Hepatocellular Carcinoma (Hepatoma) 12/2021 - 03/2007
3	IGA Glomerulonephritis (IGA Nephropathy) 01/2005 - 07/2003
2	Iron Overload 04/2020 - 11/2012
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/2018 - 11/2013
2	Nephrosclerosis 10/2016 - 01/2013
2	Hypertension (High Blood Pressure) 10/2016 - 01/2013
2	Lung Neoplasms (Lung Cancer) 06/2010 - 09/2004
2	Reperfusion Injury 08/2008 - 12/2005
2	Carcinogenesis 05/2006 - 01/2003
2	Membranous Glomerulonephritis (Membranous Nephropathy) 01/2005 - 07/2003
2	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 01/2005 - 07/2003
2	Breast Neoplasms (Breast Cancer) 12/2004 - 11/2004
1	Kidney Diseases (Kidney Disease) 03/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 03/2022
1	Infertility (Sterility) 01/2021
1	Acute Kidney Injury (Acute Renal Failure) 05/2020
1	B-Cell Lymphoma (Lymphoma, B Cell) 02/2019
1	Candidiasis (Moniliasis) 01/2019
1	Intraabdominal Infections 01/2019
1	Peritonitis 01/2019
1	Contracture 01/2017
1	Pulmonary Emphysema 06/2015

Drug/Important Bio-Agent (IBA)

13	chlorhexidine gluconate (Dyna-Hex)FDA LinkGeneric 03/2022 - 01/2003
10	Fibroblast Growth Factor 7 FDA Link 10/2015 - 01/2003
9	Fas Ligand Protein (Fas Ligand)IBA 08/2008 - 03/2002
8	Proteins (Proteins, Gene)FDA Link 10/2015 - 12/2000
7	Messenger RNA (mRNA)IBA 09/2012 - 12/2000
6	CollagenIBA 01/2017 - 01/2003
5	HSP47 Heat-Shock Proteins (Heat Shock Protein 47)IBA 01/2015 - 01/2003
4	Histones (Histone)IBA 05/2018 - 11/2013
4	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 09/2012 - 04/2002
4	Caspase 3 (Caspase-3)IBA 11/2007 - 02/2005
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2007 - 10/2002
3	AntibodiesIBA 02/2019 - 10/2002
3	EnzymesIBA 04/2015 - 10/2002
3	Snake Venoms (Snake Venom)IBA 12/2012 - 07/2008
3	Estrogen ReceptorsIBA 05/2012 - 03/2003
3	Estrogens (Estrogen)FDA Link 05/2012 - 03/2003
3	Biological ProductsIBA 10/2008 - 08/2002
3	Cytochromes c (Cytochrome c)IBA 11/2007 - 02/2005
3	Estrogen Receptor alphaIBA 09/2006 - 03/2003
2	Proliferating Cell Nuclear Antigen (PCNA)IBA 12/2021 - 04/2002
2	CateninsIBA 12/2021 - 02/2019
2	Connexin 43 (Connexin43)IBA 01/2021 - 07/2007
2	Retinaldehyde (Retinal)IBA 05/2020 - 04/2004
2	Lysine (L-Lysine)FDA Link 05/2018 - 11/2013
2	keratinocyte growth factor receptorIBA 10/2015 - 11/2014
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2015 - 11/2004
2	Histone Deacetylase InhibitorsIBA 05/2015 - 04/2013
2	ImmunosorbentsIBA 04/2015 - 10/2002
2	Molecular Chaperones (Chaperone, Molecular)IBA 01/2015 - 09/2003
2	Collagen Type III (Type III Collagen)IBA 03/2013 - 12/2008
2	azelnidipineIBA 01/2013 - 12/2008
2	olmesartanIBA 01/2013 - 12/2008
2	NF-kappa B (NF-kB)IBA 11/2012 - 07/2003
2	IronIBA 11/2012 - 03/2007
2	Small Interfering RNA (siRNA)IBA 07/2012 - 01/2008
2	Glucose (Dextrose)FDA LinkGeneric 01/2012 - 04/2004
2	Angiotensin IIIBA 01/2012 - 01/2005
2	ParaffinIBA 12/2009 - 11/2004
2	TransferasesIBA 05/2009 - 05/2007
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 05/2007 - 04/2004
2	Estrogen Receptor betaIBA 09/2006 - 03/2003
2	ReninIBA 01/2005 - 02/2004
2	Immunoglobulin A (IgA)IBA 01/2005 - 07/2003
2	AngiotensinsIBA 01/2005 - 02/2004
2	Erythromycin (Erycette)FDA LinkGeneric 06/2004 - 04/2003
2	AntigensIBA 07/2003 - 04/2003
2	Biotin (Vitamin H)FDA Link 08/2002 - 04/2002
1	4- (2,4- difluorophenyl)- 2- (1H- indol- 3- yl)- 4- oxobutanoic acidIBA 03/2022
1	indoleacetic acid (indole acetic acid)IBA 03/2022
1	tamibaroteneIBA 07/2021
1	Factor V (Coagulation Factor V)IBA 07/2021
1	ConnexinsIBA 01/2021
1	Cisplatin (Platino)FDA LinkGeneric 05/2020
1	Peptides (Polypeptides)IBA 05/2020
1	prothymosin alphaIBA 05/2020
1	EpitopesIBA 02/2019
1	Micafungin (FK463)FDA Link 01/2019
1	CytokinesIBA 01/2019
1	Enhancer of Zeste Homolog 2 ProteinIBA 05/2018
1	Collagen Type I (Type I Collagen)IBA 01/2017
1	CurcuminIBA 10/2016
1	Chondroitin Sulfates (Chondroitin Sulfate)IBA 09/2016
1	Pancreatic Elastase (Elastase)IBA 06/2015

Therapy/Procedure

9	Peritoneal Dialysis 03/2022 - 10/2004
6	Therapeutics 01/2019 - 01/2003
5	Intraperitoneal Injections 03/2022 - 01/2003
2	Hepatectomy 04/2020 - 11/2012
2	Transplantation 06/2010 - 08/2008
2	Continuous Ambulatory Peritoneal Dialysis (CAPD) 09/2003 - 01/2003